I use AVG and Symantec anti virus. Symantec's auto protect feature is disabled in Windows Vista, that's why I was able to maintain 2 anti virus software in my pc.
I am using McAfee ever since 2006. Works like a charm. For the last 6 years, never had a single bad experience. I have heard that Kasper is better than McAfee, but the former is a bit more expensive.